Why is any ‘deterioration’ in the medical condition of the patient from the index stroke documented as an SAE?

 In

This is considered as an SAE because it is possible that ‘colchicine’ has caused an opportunistic infection.

If a patient is discharged to rehab where administration of ‘study drug’ may be prohibited, what is the best course of action?
Can colchicine be crushed to facilitate oral administration?